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Volume 48S Number 2

Volume 48S Number 2

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Optimization of diagnostics and treatment in patients with uncontrolled bronchial asthma

Sh.M. Mukhtorov^a, A.A. Suyarov^a, T.U. Aripova^a

 
ABSTRACT:     This article discusses changes in clinical, laboratory, and immunological parameters in patients with BA. Immunological studies were carried out in 132 patients with bronchial asthma III and IV degree, mixed type, moderate degree, with a controlled and poorly controlled process. Analysis of sensitivity to 8 different glucocorticosteroids in the blood serum of patients with uncontrolled course of asthma revealed persistent resistance to corticosteroids in a larger number of patients. A comparative analysis of RGT and TGT was carried out. Optimization of diagnosis by determining the sensitivity to corticosteroids and the appropriate selection of adequate therapy contributes to the rapid relief of exacerbation of the disease. The study of the cytokine profile after 3 and 6 months is a good predictor of establishing control over the course of bronchial asthma.

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Received 10 Jan 2021, Accepted 29 Apr 2022