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Volume 48S Number 2

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Dynamics of changes in cytokine levels in patients with diabetic foot syndrome on the background of various types of anesthesia

Bakhtiyor Zarifovich Khamdamov^a, Usman Bebitovich Oltiev^a, Alisher Bakhtiyorovich Khamdamov^a 

 
ABSTRACT:     Comparative study of the effect of general, epidural and conduction anesthesia on the state of cytokine levels in patients with diabetic foot syndrome. 157 patients with diabetic foot syndrome were examined, which comprised 3 groups depending on the use of anesthesia methods: group I - 51 patients (32.48%) operated under epidural anesthesia (EA). Group II – 52 (33.12%) patients who were anesthetized by conduction anesthesia (PA). Group III - 54 (34.4%) patients who underwent general anesthesia (OA). The dynamics of changes in the level of cytokines VEGF-A, MCP-1, IL-18 in blood serum were studied by ELISA. It was revealed that patients who underwent general anesthesia had more profound changes in cytokine status than the initial data. The indicators are slightly better in patients who underwent epidural anesthesia. In patients who underwent surgery with the use of conductive anesthesia, the cytokine levels remained at the baseline level. Therefore, conduction anesthesia is a more gentle anesthesia with respect to its effect on cytokine status parameters. From the point of view of the dynamics of changes in the content of cytokines MCP-1 and VEGF A in blood serum, the method of choice for operations on the lower extremities in patients with diabetic foot syndrome is conductive anesthesia (PA) based on stem nerve blockades. At the same time, measurements of the content of MCP-1 and VEGF A of blood serum can be proposed as laboratory predictors and criteria for predicting the outcomes of various types of anesthesia.

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Received 10 Jan 2021, Accepted 29 Apr 2022