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Volume 48S Number 2

Volume 48S Number 2

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Peculiarities of immune status in children with chronic bronchitis

Nilufar Irgashevna Karimova^a*, Furkat Mukhitdinovich Shamsiev^a

 
ABSTRACT:     The aim of the study was to determine the state of the immune and cytokine status in chronic bronchitis in children. The results of the study showed that chronic bronchitis occurs in 10.4% of the total number of children with bronchopulmonary pathology and develops against the background of unfavorable perinatal factors, concomitant and past diseases affecting the development, course and outcome of the disease. The clinical picture and course of chronic bronchitis depend on the nature and degree of bronchial damage. The data obtained by us on the indicators of the immune status in different age groups in children with chronic bronchitis indicate suppression of indicators of cellular immunity and phagocytosis of neutrophils, activation of the humoral link of immunity, the most informative diagnostic markers of chronic diseases of the lower respiratory tract in children, manifested by overproduction of pro- and anti-inflammatory cytokines indicating chronic inflammation.

* Corresponding author, E-mail: nilufar_karimova_00@mail.ru

Received 30 Jun 2021, Accepted 16 Oct 2021