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Volume 48S Number 2

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Study and analysis of the cytokine status and features of the distribution of genotypes and alleles of the polymorphous locus of
the interleukin-10 gene in patients with viral hepatitis c with extrahepatic manifestations

Z.I.Oblokulova^a*, N.A.Nuraliev^a, A.R.Oblokulov^a

 
ABSTRACT:     It was established that a comparative analysis of the occurrence rates of the genotypes of the polymorphic locus of the IL-10 gene (G1082A) in HCV patients with extrahepatic manifestations with and without cryoglobulinemia showed that the GG genotype was significantly more common in relation to the GA and AA genotypes, respectively, at 1.57 (P ≥ 0.05) and 5.50 times (P ≤ 0.001) in HCV patients with extrahepatic manifestations with cryoglobulinemia, and the difference between the GA and AA genotypes was 3.50 times in favor of the GA genotype (P ≤ 0.001). In the examined patients without cryoglobulinemia, the occurrence of genotypes and their distribution had the same trend and variability as in patients with the presence of this phenomenon. In both groups of patients, the trend of change was identical with the results of healthy individuals. It has been established that cryoglobulenemia has practically no effect on the occurrence of genotypes and alleles of the polymorphic locus of the IL-10 gene (G1082A) in HCV patients with extrahepatic manifestations.

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Received 12 Aug 2022, Accepted 8 Nov 2022