Volume 48S Number 1

Volume 48S Number 2

Volume 48S Number 2

previous article

next article

The study of the effect of dry extract of tribulus terrestris on antibody genesis and immune organs in experimental hemolytic anemia

Farida Ashurova^a*, Nodir Ruzimurodov^a, Liliya Sabirzyanova^a, Makhzuna Mukhsinova^a

 
ABSTRACT:     The study shows that in the process of developing hemolytic anemia (with the help of phenylhydrazine hydrochloride), a secondary immunodeficiency state is formed in mice. The number of antibody-forming cells in the spleen of mice with anemia is 1212.5±27.3, which is 3.60 times less than in the control. In anemic mice treated with a dry extract of Tribulus Terrestris, the immune response to EB was significantly increased by 2.60 times. The number of antibody- forming cells is 2.97 times higher than that of the immunodeficient group. The number of nucleated cells in the spleen compared with the control is a significant (1.42 times) increase in the total number of cells in the spleen. The titer of antibodies to sheep erythrocytes in the blood significantly increases by 1.46 times compared to the control group. The number of cells in the thymus significantly increased by 1.32 times, respectively. The number of cells in the lymph nodes increases by 1.41 times. The number of erythrocytes in peripheral blood increases by 1.18 times and leukocytes by 1.42 times. In terms of its stimulating activity, the dry extract of Tribulus Terrestris significantly outperforms that of Tribestan. The whole complex of studies shows that the dry extract of Tribulus Terrestris has the ability to increase immunological reactivity and stimulate the hematopoietic system in mice with hemolytic anemia.

* Corresponding author, E-mail:

Received 8 Aug 2022, Accepted 1 Nov 2022