Volume 48S Number 1

Volume 48S Number 2

Volume 48S Number 2

previous article

next article

Antioxidant therapy metabolic approaches to the treatment of chronic brucellosis

Farmanova Makhtob Alimovna^a*, Khudoydodova Sayyora Gafurdjanovna^a, Inoyatova Feruza Khidoyatovna^b

 
ABSTRACT:     In chronic active brucellosis (CAB), patients from time to time complain of fever, trembling, sweating, weakness, shortness of breath, pain in the muscles, joints, spine, headaches, numbness in the morning, cold on the upper and lower extremities, dyspeptic symptoms, weakening cognitive functions. According to scientists, clinical, laboratory and functional examinations are associated with changes and multifocal fibrosis of organs and tissues of the body, as well as an increase in lymph nodes, the direct spread of Brucella to all organs and tissues of the body, which will lead to multiple organ insufficiency. Evaluation of the effectiveness of the treatment of patients with chronic active brucellosis with phosphargin succinate. 85 patients aged 17-74 who were treated in the Bukhara Regional Hospital for Acute Diseases, living in regional endemic areas, were taken as the object of the study. 64 (75.3%) of them are men and 21 (24.7%) are women. Distribution of patients by age according to the WHO classification showed that the incidence is mainly characteristic of young age (78.5%) (see Table 1). The average age of the patients was 36.18±1.99 years. According to clinical forms, patients were divided as follows: primary chronic brucellosis (PCHB) – 22 (25.8%) and secondary chronic brucellosis (SCHB) – 63 (74.2%). No gender differences were found in either form. In PCHB, it was mostly typical of advanced age, while in SCHB, 73% of advanced and 20.6% were typical of middle age. Chronic brucellosis is characterized by an increase in the amount of MD, a weakening of the antioxidant defense system, and a decrease in the compensatory capacity of the antioxidant system, and their changes depend on the severity of the disease.

* Corresponding author, E-mail:

Received 30 May 2022, Accepted 20 Sep 2022